DISCOVER-EEG: an open, fully automated EEG pipeline for biomarker discovery in clinical neurosciences. OPEN ACCESS

Gil Avila C, Bott FS, Tiemann L, Hohn VD, May ES, Nickel MM, Zebhauser PT, Gross J, Ploner M

Sci Data. 2023. 10: 613. doi: 10.1038/s41597-023-02525-0.

Resting-state EEG and MEG biomarkers of pathological fatigue - A transdiagnostic systematic reviewOPEN ACCESS

Heitmann H, Zebhauser PT, Hohn VD, Henningsen H, Ploner M

Neuroimage Clin. 2023. 39: 103500. doi: 10.1016/j.nicl.2023.103500.

Next steps for global collaboration to minimize racial and ethnic bias in neuroscience. 

Müller R, Ruess AK, Scönweitz FB, Buyx A, Gil Ávila C, Ploner M

Nat Neurosci. 2023. 26:1122-1123. doi: 10.1038/s41593-023-01369-6.

Local brain oscillations and interregional connectivity differentially serve sensory and expectation effects on pain. OPEN ACCESS

Bott FS, Nickel MM, Hohn VD, May ES, Gil Avila C, Tiemann L, Gross J, Ploner M

Sci Adv. 2023. 9:eadd7572. doi: 10.1126/sciadv.add7572.

Reengineering neurotechnology: placing patients first.

Ploner M, Buyx A, Gempt J, Gjorgijeva J, Müller R, Priller J, Rückert D, Wolfrum B, Jacob S 

Nat Ment Health. 2023. 1:5-7. doi: 10.1038/s44220-022-00011-x.

Resting state EEG and MEG as biomarkers of chronic pain: a systematic review. OPEN ACCESS

Zebhauser PT, Hohn VD, Ploner M.

Pain. 2023. 164:1200-1221. doi: 10.1097/j.pain.0000000000002825.


How do alpha oscillations shape the perception of pain? - An EEG-based neurofeedback study. OPEN ACCESS

Hohn VD, Bott FS, May ES, Tiemann L, Fritzen C, Nickel MM, Gil Ávila C, Ploner M

PLoS Biol, Registered Report, in-principle accepted. 2022. doi: 10.17605/OSF.IO/QBKJ2.

Hippocampus mediates nocebo impairment of opioid analgesia through changes in functional connectivity.  OPEN ACCESS

Bingel U*, Wiech K*, Ritter C, Wanigasekera V, Ní Mhuircheartaigh R, Lee MC, Ploner M, Tracey I

Eur J Neurosci. 2022. 56:3967-3978. doi: 10.1111/ejn.15687. 

*equal contribution

Common and specific large-scale brain changes in major depressive disorder, anxiety disorders, and chronic pain: a transdiagnostic multimodal meta-analysis of structural and functional MRI studies. OPEN ACCESS

Brandl F, Weise B, Mulej Bratec S, Jassim N, Hoffmann Ayala D, Bertram T, Ploner M, Sorg C

Neuropsychopharmacology. 2022. 47:1071-1080. doi: 10.1038/s41386-022-01271-y.

Longitudinal resting-state electroencephalography in patients with chronic pain undergoing interdisciplinary multimodal pain therapy. OPEN ACCESS

Heitmann H, Gil Ávila C, Nickel MM, Ta Dinh S, May ES, Tiemann L, Hohn VD, Tölle TR, Ploner M. 

Pain. 2022. 63:e997-e1005. doi: 10.1097/j.pain.0000000000002565.

Temporal-spectral signaling of sensory information and expectations in the cerebral processing of pain.      OPEN ACCESS

Nickel MM, Tiemann L, Hohn VD, May ES, Gil Avila C, Eippert F, Ploner M.

Proc Natl Acad Sci USA. 2022119:e2116616119. doi: 10.1073/pnas.2116616119.


Modulating brain rhythms of pain using transcranial alternating current stimulation (tACS) - A sham-controlled study in healthy human participants. OPEN ACCESS

May ES*, Hohn VD*, Nickel MM, Tiemann L, Gil Ávila C, Heitmann H, Sauseng P, Ploner M.

J Pain. 2021. 22:1256-1272. doi: 10.1016/j.jpain.2021.03.150.

*equal contribution

Exploring Dynamic Connectivity Biomarkers of Neuropsychiatric Disorders.

Ploner M, Tiemann L.

Trends Cogn Sci. 202125(5):336-338. doi: 10.1016/j.tics.2021.03.005. 

Dynamics of brain function in chronic pain patients assessed by microstate analysis of resting-state electroencephalography. OPEN ACCESS

May ES*, Gil Ávila C*, Ta Dinh S, Heitmann H, Hohn VD, Nickel MM, Tiemann L, Tölle TR, Ploner M.

Pain. 2021. 162:2894-2908. doi: 10.1097/j.pain.0000000000002281.

*equal contribution


Fatigue, depression, and pain in multiple sclerosis: How neuroinflammation translates into dysfunctional reward processing and anhedonic symptomsOPEN ACCESS

Heitmann H, Andlauer TFM, Korn T, Mühlau M, Henningsen P, Hemmer B, Ploner M. 

Mult Scler. 2020. doi: 10.1177/1352458520972279

Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study. OPEN ACCESS

Heitmann H, Haller B, Tiemann L, Mühlau M, Berthele A, Tölle TR, Salmen A, Ambrosius B, Bayas A, Asseyer S, Hartung HP, Heesen C, Stangel M, Wildemann B, Haars S, Groppa S, Luessi F, Kümpfel T, Nischwitz S, Meuth SG, Klotz L, Linker RA, Zettl UK, Ziemann U, Tumani H, Tackenberg B, Zipp F, Wiendl H, Gold R, Hemmer B, Ploner M.

Pain. 2020; 161(4): 787-796. doi: 10.1097/j.pain.0000000000001767.

Neural oscillations and connectivity characterizing the state of tonic experimental pain in humans.                OPEN ACCESS

Nickel MM, Ta Dinh S, May ES, Tiemann L, Hohn VD, Gross J, Ploner M.

Hum Brain Mapp. 2020; 41(1):17-29. doi: 10.1002/hbm.24784.


Brain dysfunction in chronic pain patients assessed by resting-state electroencephalography. OPEN ACCESS

Ta Dinh S, Nickel MM, Tiemann L, May ES, Heitmann H, Hohn VD, Edenharter G, Utpadel-Fischler D, Tölle TR, Sauseng P, Gross J, Ploner M.

Pain. 2019; 160(12):2751-2765. doi: 10.1097/j.pain.0000000000001666. 

Perceptual and motor responses directly and indirectly mediate the effects of noxious stimuli on autonomic responses. 

Tiemann L, Hohn VD, Ta Dinh S, May ES, Nickel MM, Heitmann H, Ploner M.

Pain. 2019; 160(12):2811-2818. doi: 10.1097/j.pain.0000000000001661. 

From correlations to causality: modulating brain rhythms of pain using transcranial alternating current stimulation. OPEN ACCESS

Hohn VD, May ES, Ploner M.

Pain Rep. 20194(4):e723. doi: 10.1097/PR9.0000000000000723. 

Gamma oscillations shape pain in animals and humans.

Ploner M, Gross J.

Trends Cogn Sci. 2019; 23(6):450-1. doi: 10.1016/J.TICS.2019.04.001. 

Prefrontal gamma oscillations reflect ongoing pain intensity in chronic back pain patients. OPEN ACCESS

May ES, Nickel MM, Ta Dinh S, Tiemann L, Heitmann H, Voth I, Tölle TR, Gross J, Ploner M.

Hum Brain Mapp. 2019 Jan;40(1):293-305. doi: 10.1002/hbm.24373. 


Motor Responses to Noxious Stimuli Shape Pain Perception in Chronic Pain Patients. OPEN ACCESS

Heitmann H*, May ES*, Tiemann L, Schmidt P, Nickel MM, Ta Dinh S, Hohn VD, Tölle TR, Ploner M.

eNeuro. 2018 Nov 29;5(5). pii: ENEURO.0290-18.2018. doi: 10.1523/ENEURO.0290-18.2018.

*equal contribution

Distinct patterns of brain activity mediate perceptual and motor and autonomic responses to noxious stimuli. OPEN ACCESS

Tiemann L, Hohn VD, Ta Dinh S, May ES, Nickel MM, Gross J, Ploner M.

Nat Commun. 2018 Oct 26;9(1):4487. doi: 10.1038/s41467-018-06875-x. 

Electroencephalography and magnetoencephalography in pain research - current state and future perspectives.

Ploner M, May ES.

Pain. 2018 Feb;159(2):206-211. doi: 10.1097/j.pain.0000000000001087. 


Autonomic responses to tonic pain are more closely related to stimulus intensity than to pain intensity.

Nickel MM, May ES, Tiemann L, Postorino M, Ta Dinh S, Ploner M.

Pain. 2017 Nov;158(11):2129-2136. doi: 10.1097/j.pain.0000000000001010. 

Influence of pain on motor preparation in the human brain. OPEN ACCESS

Postorino M, May ES, Nickel MM, Tiemann L, Ploner M.

J Neurophysiol. 2017 Oct 1;118(4):2267-2274. doi: 10.1152/jn.00489.2017. 

Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations. OPEN ACCESS

Davis KD, Flor H, Greely HT, Iannetti GD, Mackey S, Ploner M, Pustilnik A, Tracey I, Treede RD, Wager TD.

Nat Rev Neurol. 2017 Oct;13(10):624-638. doi: 10.1038/nrneurol.2017.122. 

The effects of treatment failure generalize across different routes of drug administration.

Zunhammer M, Ploner M, Engelbrecht C, Bock J, Kessner SS, Bingel U.

Sci Transl Med. 2017 Jun 7;9(393). pii: eaal2999. doi: 10.1126/scitranslmed.aal2999. 

Behavioral responses to noxious stimuli shape the perception of pain. OPEN ACCESS

May ES, Tiemann L, Schmidt P, Nickel MM, Wiedemann N, Dresel C, Sorg C, Ploner M.

Sci Rep. 2017 Mar 9;7:44083. doi: 10.1038/srep44083. 

Brain oscillations differentially encode noxious stimulus intensity and pain intensity. OPEN ACCESS

Nickel MM, May ES, Tiemann L, Schmidt P, Postorino M, Ta Dinh S, Gross J, Ploner M.

Neuroimage. 2017 Mar 1;148:141-147. doi: 10.1016/j.neuroimage.2017.01.011. 

Brain Rhythms of Pain. OPEN ACCESS

Ploner M, Sorg C, Gross J. 

Trends Cogn Sci. 2017 Feb;21(2):100-110. doi: 10.1016/j.tics.2016.12.001. 


Prevalence of neuropathic pain in early multiple sclerosis.

Heitmann H, Biberacher V, Tiemann L, Buck D, Loleit V, Selter RC, Knier B, Tölle TR, Mühlau M, Berthele A, Hemmer B, Ploner M.

Mult Scler. 2016 Aug;22(9):1224-30. doi: 10.1177/1352458515613643. 

Spontaneous Cerebrospinal Fluid Leak With Venous Engorgement Mimicking a Contrast-Enhancing Cervical Mass.

Herwerth M, Prothmann S, Kreiser K, Hemmer B, Ploner M.

JAMA Neurol. 2016 Jul 1;73(7):886-7. doi: 10.1001/jamaneurol.2016.0277. 

Metabolic connectivity mapping reveals effective connectivity in the resting human brain.

Riedl V, Utz L, Castrillón G, Grimmer T, Rauschecker JP, Ploner M, Friston KJ, Drzezga A, Sorg C.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):428-33. doi: 10.1073/pnas.1513752113. 


Prefrontal Gamma Oscillations Encode Tonic Pain in Humans.

Schulz E, May ES, Postorino M, Tiemann L, Nickel MM, Witkovsky V, Schmidt P, Gross J, Ploner M.

Cereb Cortex. 2015 Nov;25(11):4407-14. doi: 10.1093/cercor/bhv043. 

Frontostriatal Gating of Tinnitus and Chronic Pain.

Rauschecker JP, May ES, Maudoux A, Ploner M.

Trends Cogn Sci. 2015 Oct;19(10):567-578. doi: 10.1016/j.tics.2015.08.002. 

Extensive Recruitment of Plasma Blasts to the Cerebrospinal Fluid in Toscana Virus Encephalitis.

Schirmer L, Wölfel S, Georgi E, Ploner M, Bauer B, Hemmer B.

Open Forum Infect Dis. 2015 Sep 1;2(3):ofv124. doi: 10.1093/ofid/ofv124.

Towards a taxonomy of pain modulations.

Ploner M, Bingel U, Wiech K.

Trends Cogn Sci. 2015 Apr;19(4):180-2. doi: 10.1016/j.tics.2015.02.007. 

Differential neurophysiological correlates of bottom-up and top-down modulations of pain.

Tiemann L, May ES, Postorino M, Schulz E, Nickel MM, Bingel U, Ploner M.

Pain. 2015 Feb;156(2):289-96. doi: 10.1097/01.j.pain.0000460309.94442.44. 


Dissociable neural mechanisms underlying the modulation of pain and anxiety? An FMRI pilot study.

Wiech K, Edwards R, Moseley GL, Berna C, Ploner M, Tracey I.

PLoS One. 2014 Dec 15;9(12):e110654. doi: 10.1371/journal.pone.0110654. 

The effect of treatment history on therapeutic outcome: psychological and neurobiological underpinnings.

Kessner S, Forkmann K, Ritter C, Wiech K, Ploner M, Bingel U.

PLoS One. 2014 Oct 2;9(9):e109014. doi: 10.1371/journal.pone.0109014. 

Dopamine precursor depletion influences pain affect rather than pain sensation.

Tiemann L, Heitmann H, Schulz E, Baumkötter J, Ploner M.

PLoS One. 2014 Apr 23;9(4):e96167. doi: 10.1371/journal.pone.0096167. 


The effect of treatment history on therapeutic outcome: an experimental approach.

Kessner S, Wiech K, Forkmann K, Ploner M, Bingel U.

JAMA Intern Med. 2013 Aug 12;173(15):1468-9. doi: 10.1001/jamainternmed.2013.6705. 

Amygdala activity contributes to the dissociative effect of cannabis on pain perception.

Lee MC, Ploner M, Wiech K, Bingel U, Wanigasekera V, Brooks J, Menon DK, Tracey I.

Pain. 2013 Jan;154(1):124-34. doi: 10.1016/j.pain.2012.09.017. 


Decoding the perception of pain from fMRI using multivariate pattern analysis.

Brodersen KH, Wiech K, Lomakina EI, Lin CS, Buhmann JM, Bingel U, Ploner M, Stephan KE, Tracey I.

Neuroimage. 2012 Nov 15;63(3):1162-70. doi: 10.1016/j.neuroimage.2012.08.035. 

γ Oscillations are involved in the sensorimotor transformation of pain.

Schulz E, Tiemann L, Witkovsky V, Schmidt P, Ploner M.

J Neurophysiol. 2012 Aug;108(4):1025-31. doi: 10.1152/jn.00186.2012. 

Decoding an individual's sensitivity to pain from the multivariate analysis of EEG data.

Schulz E, Zherdin A, Tiemann L, Plant C, Ploner M.

Cereb Cortex. 2012 May;22(5):1118-23. doi: 10.1093/cercor/bhr186. 

Behavioral and neuronal investigations of hypervigilance in patients with fibromyalgia syndrome.

Tiemann L, Schulz E, Winkelmann A, Ronel J, Henningsen P, Ploner M.

PLoS One. 2012;7(4):e35068. doi: 10.1371/journal.pone.0035068. 


Neurophysiological coding of traits and states in the perception of pain.

Schulz E, Tiemann L, Schuster T, Gross J, Ploner M.

Cereb Cortex. 2011 Oct;21(10):2408-14. doi: 10.1093/cercor/bhr027. 

Flexible cerebral connectivity patterns subserve contextual modulations of pain.

Ploner M, Lee MC, Wiech K, Bingel U, Tracey I.

Cereb Cortex. 2011 Mar;21(3):719-26. doi: 10.1093/cercor/bhq146. 

The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil.

Bingel U, Wanigasekera V, Wiech K, Ni Mhuircheartaigh R, Lee MC, Ploner M, Tracey I.

Sci Transl Med. 2011 Feb 16;3(70):70ra14. doi: 10.1126/scitranslmed.3001244. 

Modulation of human time processing by subthalamic deep brain stimulation.

Wojtecki L, Elben S, Timmermann L, Reck C, Maarouf M, Jörgens S, Ploner M, Südmeyer M, Groiss SJ, Sturm V, Niedeggen M, Schnitzler A.

PLoS One. 2011;6(9):e24589. doi: 10.1371/journal.pone.0024589. 


Differential effects of painful and non-painful stimulation on tactile processing in fibromyalgia syndrome and subjects with masochistic behaviour.

Pollok B, Krause V, Legrain V, Ploner M, Freynhagen R, Melchior I, Schnitzler A.

PLoS One. 2010 Dec 28;5(12):e15804. doi: 10.1371/journal.pone.0015804. 

Anterior insula integrates information about salience into perceptual decisions about pain.

Wiech K, Lin CS, Brodersen KH, Bingel U, Ploner M, Tracey I.

J Neurosci. 2010 Dec 1;30(48):16324-31. doi: 10.1523/JNEUROSCI.2087-10.2010. 

Gamma oscillations as a neuronal correlate of the attentional effects of pain.

Tiemann L, Schulz E, Gross J, Ploner M.

Pain. 2010 Aug;150(2):302-8. doi: 10.1016/j.pain.2010.05.014. 

Prestimulus functional connectivity determines pain perception in humans.

Ploner M, Lee MC, Wiech K, Bingel U, Tracey I.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):355-60. doi: 10.1073/pnas.0906186106. 


Functional integration within the human pain system as revealed by Granger causality.

Ploner M, Schoffelen JM, Schnitzler A, Gross J.

Hum Brain Mapp. 2009 Dec;30(12):4025-32. doi: 10.1002/hbm.20826. 

Perceptual decisions: from sensory signals to behavior.

Gross J, Ploner M.

Curr Biol. 2009 Sep 29;19(18):R847-9. doi: 10.1016/j.cub.2009.07.023. 


Neurocognitive aspects of pain perception.

Wiech K, Ploner M, Tracey I.

Trends Cogn Sci. 2008 Aug;12(8):306-13. doi: 10.1016/j.tics.2008.05.005. 

Impaired cerebral oscillatory processing in hepatic encephalopathy.

Timmermann L, Butz M, Gross J, Ploner M, Südmeyer M, Kircheis G, Häussinger D, Schnitzler A.

Clin Neurophysiol. 2008 Feb;119(2):265-72. 

Differential effects of levodopa and subthalamic nucleus deep brain stimulation on bradykinesia in Parkinson's disease.

Timmermann L, Braun M, Groiss S, Wojtecki L, Ostrowski S, Krause H, Pollok B, Südmeyer M, Ploner M, Gross J, Maarouf M, Voges J, Sturm V, Schnitzler A.

Mov Disord. 2008 Jan 30;23(2):218-27. 


Evoked response amplitudes from somatosensory cortices do not determine reaction times to tactile stimuli.

Ploner M, Platzen J, Pollok B, Gross J, Schnitzler A.

Eur J Neurosci. 2007 Jun;25(12):3734-41. 

Gamma oscillations in human primary somatosensory cortex reflect pain perception.

Gross J, Schnitzler A, Timmermann L, Ploner M.

PLoS Biol. 2007 May;5(5):e133. 


Wilson's disease tremor is associated with magnetic resonance imaging lesions in basal ganglia structures.

Südmeyer M, Saleh A, Wojtecki L, Cohnen M, Gross J, Ploner M, Hefter H, Timmermann L, Schnitzler A.

Mov Disord. 2006 Dec;21(12):2134-9. 

Acute axonal neuropathy and Wernicke's encephalopathy.

Lehmann HC, Lindenberg R, Arendt G, Ploner M.

J Neurol. 2006 Nov;253(11):1516-7. 

Pain processing is faster than tactile processing in the human brain.

Ploner M, Gross J, Timmermann L, Schnitzler A.

J Neurosci. 2006 Oct 18;26(42):10879-82. 

Oscillatory activity reflects the excitability of the human somatosensory system.

Ploner M, Gross J, Timmermann L, Pollok B, Schnitzler A.

Neuroimage. 2006 Sep;32(3):1231-6. 

Pain suppresses spontaneous brain rhythms.

Ploner M, Gross J, Timmermann L, Pollok B, Schnitzler A.

Cereb Cortex. 2006 Apr;16(4):537-40. 


Herpes encephalitis after meningioma resection.

Ploner M, Turowski B, Wöbker G.

Neurology. 2005 Nov 22;65(10):1674-5. 


[Cortical representation of pain].

Ploner M, Schnitzler A..

Nervenarzt. 2004 Oct;75(10):962-9. 

Pain facilitates tactile processing in human somatosensory cortices.

Ploner M, Pollok B, Schnitzler A.

J Neurophysiol. 2004 Sep;92(3):1825-9. 


Wernicke's encephalopathy.

Ploner M, Schnitzler A.

Lancet. 2003 Mar 22;361(9362):1000. 


Cortical representation of first and second pain sensation in humans.

Ploner M, Gross J, Timmermann L, Schnitzler A.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12444-8. 

Cortical representation of venous nociception in humans.

Ploner M, Holthusen H, Noetges P, Schnitzler A.

J Neurophysiol. 2002 Jul;88(1):300-5. 


Differential coding of pain intensity in the human primary and secondary somatosensory cortex.

Timmermann L, Ploner M, Haucke K, Schmitz F, Baltissen R, Schnitzler A.

J Neurophysiol. 2001 Sep;86(3):1499-503. 

Behavioural relevance modulates access to spatial working memory in humans.

Ploner CJ, Ostendorf F, Brandt SA, Gaymard BM, Rivaud-Péchoux S, Ploner M, Villringer A, Pierrot-Deseilligny C.

Eur J Neurosci. 2001 Jan;13(2):357-63. 


Neurophysiology and functional neuroanatomy of pain perception.

Schnitzler A, Ploner M.

J Clin Neurophysiol. 2000 Nov;17(6):592-603. 

Separate representations of static and dynamic touch in human somatosensory thalamus.

Timmermann L, Ploner M, Freund HJ, Schnitzler A.

Neurology. 2000 May 23;54(10):2024-6. 

Differential organization of touch and pain in human primary somatosensory cortex.

Ploner M, Schmitz F, Freund HJ, Schnitzler A.

J Neurophysiol. 2000 Mar;83(3):1770-6. 


Parallel activation of primary and secondary somatosensory cortices in human pain processing.

Ploner M, Schmitz F, Freund HJ, Schnitzler A.

J Neurophysiol. 1999 Jun;81(6):3100-4. 

Pain affect without pain sensation in a patient with a postcentral lesion.

Ploner M, Freund HJ, Schnitzler A.

Pain. 1999 May;81(1-2):211-4.